Epileptology Clinic

The Epileptology Clinic at Erasme Hospital, H.U.B, specialises in the diagnosis, treatment and follow-up of people with epilepsy or epileptic seizures.

Diagnose and treat epilepsy

Epilepsy affects approximately 1% of the population and can occur at any age. In one-third of cases, anti-epileptic medicines are unable to control it. The impact on daily life, particularly the ability to work and drive a vehicle, can then be significant.

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Clinique d'épilepsie - Hôpital Erasme H.U.B - Illu scan cerveau
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Clinique d'épilepsie - Hôpital Erasme H.U.B - Illu homme en crise d'épilepsie
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Clinique d'épilepsie - Hôpital Erasme H.U.B - Ondes cérébrales EEG illu

Freeing patients from epileptic seizures

The Epileptology Clinic provides care for adult patients with epilepsy of any type and severity. The goals of care are freedom from seizures and a better quality of life.

Your reference centre in Brussels

Neurologists, neurophysiologists, neurosurgeons, neuroradiologists, psychologists and specialist nurses work together to provide personalised care for patients. The Epilepsy Clinic of Erasme Hospital H.U.B is part of the Reference Centre for the management of refractory epilepsy, recognised by INAMI.

Our healthcare services

  • Specialised outpatient consultations
  • Specialist consultations for patients admitted to the Emergency Department or hospitalised, particularly in the Intensive Care Unit
  • Prolonged video-EEG recordings (24 hours or several days) for the diagnosis of epilepsy and the pre-surgical assessment of refractory epilepsies in the specialised epilepsy monitoring unit
  • Intracranial EEG recordings for the management of refractory epilepsies requiring surgery
  • Prolonged inpatient EEG recordings, particularly in the Intensive Care Unit, to diagnose epileptic seizures in critically ill patients, assess neurological prognosis in comatose patients or, for example, detect delayed cerebral ischaemia

Our team

Dr Benjamin Legros, Director of the Adult Epilepsy Clinic

Our doctors

  • Prof. Nicolas Gaspard, Head of the Neurology Department
  • Prof. Chantal Depondt
  • Prof. Lorenzo Ferlini
  • Dr Romain Tortuyaux
  • Dr Sarah Caroyer

Our nursing staff

  • Head nurse: Nathalie Buffe
  • Deputy head nurse: Didier Depré

The departments with which we collaborate

Service de Pédiatrie - Hôpital Erasme / HUDERF - H.U.B
Neuropaediatrics
Lien vers Neuropaediatrics
Neurochirurgie - icône - Hôpital Universitaire de Bruxelles
Neurosurgery
Lien vers Neurosurgery
Service d'Imagerie Médicale Hôpital Erasme H.U.B icône
Radiology and medical imaging
Lien vers Radiology and medical imaging
Service de Médecine Nucléaire Hôpital Erasme H.U.B icône
Nuclear medicine
Lien vers Nuclear medicine
Neuroradiologie interventionnelle icône
Interventional neuroradiology
Lien vers Interventional neuroradiology
Neuropsychologie et logopédie - icône
Neuropsychology
Lien vers Neuropsychology
Neuro-imagerie translationnelle - icône
Translational neuroimaging
Lien vers Translational neuroimaging

Details of the multidisciplinary collaboration of the H.U.B Epileptology Clinic

Neuropaediatrics

Children with epilepsy receive care tailored to their age and development. When routine tests do not make it possible to identify the exact origin of the seizures, doctors may, in certain situations, record the brain’s electrical activity directly using small electrodes temporarily placed inside the brain (intracerebral EEG). This examination makes it possible to locate the area responsible for the seizures with great precision.

Neurosurgery

When medication is not sufficient to control the seizures, surgery may be considered. Depending on the situation, the neurosurgeon may remove or isolate the small area of the brain responsible for the seizures so that it can no longer trigger them. Before this procedure, it may sometimes be necessary to temporarily place fine electrodes in the brain to record brain activity and precisely locate the region responsible for the seizures. When surgery is not possible or is not the best option, other treatments may be offered. In particular, it is possible to implant a small stimulator, comparable to a pacemaker, which sends mild electrical impulses to a nerve in the neck (the vagus nerve) or directly to certain areas of the brain. In some patients, these stimulations can reduce the frequency or intensity of the seizures. In certain very specific situations, a minimally invasive technique using a laser beam (LITT) may also be offered. Guided with very high precision, the laser makes it possible to treat the area responsible for the seizures without open surgery.

Radiology and medical imaging

Imaging examinations (MRI, CT scan, etc.) make it possible to obtain highly detailed images of the brain in order to look for an abnormality that may be responsible for the seizures. Some examinations also show how different regions of the brain function.

Nuclear medicine

A PET scan is an imaging examination that makes it possible to observe how the brain functions by measuring the activity of its different regions. It helps doctors identify the areas involved in the seizures when these are not visible on an MRI.

Interventional neuroradiology

Before certain surgical procedures, specialised examinations make it possible to determine which areas of the brain are involved in essential functions such as language or memory. The team also performs a highly precise mapping of the brain’s blood vessels in order to safely prepare for the placement of electrodes when necessary.

Neuropsychology and Speech Therapy

Tests make it possible to assess memory, attention, concentration, language and other cognitive functions. They help measure the impact of epilepsy on daily life and prepare for possible surgery.

Translational neuroimaging

The clinic has access to cutting-edge technology known as magnetoencephalography (MEG). This completely painless and non-invasive examination measures the very weak magnetic fields naturally produced by brain activity. It makes it possible to locate the areas responsible for the seizures with a very high degree of precision and complements the other examinations. Erasme Hospital is currently the only hospital in Belgium to have this technology.

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Scan cerveau et microscope

Research and innovation

As an academic hospital and referral centre for the management of complex epilepsies, our clinic places research at the heart of its mission. The scientific knowledge acquired in the laboratory and at patients’ bedsides directly contributes to the improvement of the care, diagnosis and treatments offered.

Our teams participate in numerous national and international research projects, as well as in clinical trials aimed at improving our understanding of the mechanisms of epilepsy, developing new diagnostic approaches and evaluating innovative treatments. 

The scientific publications of our doctors and researchers demonstrate this expertise and their commitment to advancing care for people living with epilepsy.

Our scientific publications (1/3)

Lien vers https://www.nature.com/articles/s41588-023-01485-w

GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture

International League Against Epilepsy Consortium on Complex Epilepsies. Nat Genet. 2023 Sep;55(9):1471-1482. 

Lien vers https://pubmed.ncbi.nlm.nih.gov/39363051/

Exome sequencing of 20,979 individuals with epilepsy reveals shared and distinct ultra-rare genetic risk across disorder subtypes

Epi25 Collaborative. Nat Neurosci. 2024 Oct;27(10):1864-1879. 

Lien vers https://pubmed.ncbi.nlm.nih.gov/39480921/

Brain malformations and seizures caused by impaired TRiC chaperonin function

Kraft F, Rodriguez-Aliaga P, Yuan W, Franken L, Zajt K, Hasan D, Lee TT, Flex E, Hentschel A, Innes AM, Zheng B, Julia Suh DS, Knopp C, Lausberg E, Krause J, Zhang X, Trapane P, Carroll R, McClatchey M, Fry AE, Wang L, Giesselmann S, Hoang H, Baldridge D, Silverman GA, Radio FC, Bertini E, Ciolfi A, Blood KA, de Sainte Agathe JM, Charles P, Bergant G, Čuturilo G, Peterlin B, Diderich K, Streff H, Robak L, Oegema R, van Binsbergen E, Herriges J, Saunders CJ, Maier A, Wolking S, Weber Y, Lochmüller H, Meyer S, Aleman A, Polavarapu K, Nicolas G, Goldenberg A, Guyant L, Pope K, Hehmeyer KN, Monaghan KG, Quade A, Smol T, Caumes R, Duerinckx S, Depondt C, Van Paesschen W, Rieubland C, Poloni C, Guipponi M, Arcioni S, Meuwissen M, Jansen AC, Rosenblum J, Haack TB, Bertrand M, Gerstner L, Magg J, Riess O, Schulz JB, Wagner N, Wiesmann M, Weis J, Eggermann T, Begemann M, Roos A, Häusler M, Schedl T, Tartaglia M, Bremer J, Pak SC, Frydman J, Elbracht M, Kurth I. Science. 2024 Nov;386(6721):516-525.

Lien vers https://pubmed.ncbi.nlm.nih.gov/40592404/

Diagnostic yield of clinical exome sequencing in 868 children with neurodevelopmental disorders

Neuens S, Soblet J, Penninckx A, Detry C, Badoer C, Desmyter L, Peyrassol X, Wilkin F, Busson A, Bruneau M, Grenet ML, Le Morillon A, Aeby A, Deconinck N, Prigogine C, Monier A, Juvené E, Balfroid T, Van Hecke A, Christiaens F, Depondt C, Brachet C, Delvenne V, Lufin N, Bouysran Y, Kammoun M, Daneels D, Caljon B, Croes D, Olsen C, Van Dooren S, Migeotte I, Vandernoot I, Marangoni M, Coppens S, Smits G, Vilain C. Eur J Med Genet. 2025 Aug;76:105030. 

Our scientific publications (2/3)

Lien vers https://pubmed.ncbi.nlm.nih.gov/34049028/

Assessment of a standardized EEG reactivity protocol after cardiac arrest

Caroyer S, Depondt C, Rikir E, Mavroudakis N, Peluso L, Taccone FS, Legros B, Gaspard N. Clin Neurophysiol. 2021 Jul;1 32(7):1 687-1693.

Lien vers https://pubmed.ncbi.nlm.nih.gov/41937627/

Added prognostic value of EEG reactivity in post-anoxic comatose patients

Caroyer S, Obrecht M, Damien C, De Maeseneire C, Depondt C, Rikir E, Mavroudakis N, Annoni F, Taccone FS, Legros B, Gaspard N. Annals of Clinical and Translational Neurology. In press

Lien vers https://pubmed.ncbi.nlm.nih.gov/33765473/

False-predictive EEG and clinical signs after post-anoxic brain injury under sevoflurane anaesthesia

Peluso L, Legros B, Caroyer S, Taccone FS, Gaspard N. Clin Neurophysiol. May 2021;1 32(5):1 080–1082. S P

Lien vers https://pubmed.ncbi.nlm.nih.gov/40720710/

Characteristics, Outcomes, and Treatment of Post-Anoxic Status Epilepticus: A Pooled Analysis of Three Cohorts

De Stefano P, Hofmeijer J, Quintard H, Damien C, Misirocchi F, Caroyer S, Horn J, et al. (TELSTAR investigators). Neurology. 2025 Aug 26;1 05(4):e 213913.

Our scientific publications (3/3)

Lien vers https://pubmed.ncbi.nlm.nih.gov/41934725/

Clinical applications of EEG connectivity in acute brain injuries: A systematic review

Anzalone L, Cottin L, Caroyer S, Nonclercq A, Gaspard N. Clin Neurophysiol. 2026 Apr 1;187:2111868. doi: 10.1016/j.clinph.2026.2111868

Lien vers https://pubmed.ncbi.nlm.nih.gov/41963278/

Monitoring Consciousness and Predicting Outcomes Using EEG Connectivity in Severe Traumatic Brain Injury

Anzalone L, Deschamps M, Cottin L, Caroyer S, Damien C, De Maeseneire C, Depondt C, Legros B, Nonclercq A, Gaspard N. J Neurotrauma. 2026 Apr 10:8977151261442469. doi: 10.1177/08977151261442469

FAQ – Epilepsy

  • 1. What is epilepsy?

    Epilepsy is a neurological disorder that causes recurrent seizures due to abnormal electrical activity in the brain. There are many forms of epilepsy, with symptoms that vary greatly from one person to another.

  • 2. What are the symptoms of an epileptic seizure?

    An epileptic seizure is not limited to convulsions. It can also cause loss of consciousness, a brief absence lasting a few seconds, involuntary movements, unusual sensations, speech or visual disturbances. The symptoms vary depending on the area of the brain affected.

  • 3. How is epilepsy diagnosed?

    Diagnosis is based on a medical consultation, analysis of the seizures described by the patient or their relatives, a neurological examination, and additional tests such as an electroencephalogram (EEG), which records the brain’s electrical activity, and a brain MRI.

  • 4. Can epilepsy be treated?

    Yes. In most cases, seizures can be controlled with medication. When medication is not sufficiently effective, other solutions may be considered, such as surgery, neurostimulation or certain minimally invasive techniques.

  • 5. Can one live a normal life with epilepsy?

    Yes. With appropriate treatment and specialised follow-up, most people with epilepsy can work, pursue leisure activities, travel and lead an active life. However, certain precautions may be necessary depending on the type of seizures.

  • 6. What are the causes of epilepsy?

    There are multiple causes. Epilepsy may be related to a brain malformation, a cerebrovascular accident, a head injury, a tumour, a genetic disease or an infection. In many cases, no specific cause is identified.

  • 7. When should you consult an epilepsy specialist?

    It is advisable to consult a neurologist after a first unexplained seizure, if seizures persist despite treatment, or when their cause remains difficult to identify. Care at a specialised centre helps refine the diagnosis and assess the various treatment options.

  • 8. What should you do when someone has an epileptic seizure?

    Remain calm, protect the person from injury, loosen clothing around the neck, and place them on their side as soon as possible after the seizure. Never try to restrain their movements or put anything in their mouth. If the seizure lasts more than five minutes or if several seizures occur one after another, call the emergency services.

  • 9. When is epilepsy surgery considered?

    Surgery may be considered when seizures persist despite several properly conducted treatments and a specific area of the brain is identified as the source of the seizures. Each case is thoroughly assessed by a multidisciplinary team.

  • 10. Why consult a centre specialising in epilepsy?

    A specialised centre has expert teams and access to high-tech examinations, enabling accurate diagnosis and the most appropriate treatments, including for the most complex forms of epilepsy. Patients may also benefit from innovative approaches and, in some cases, participate in clinical studies.